Pathomorphology and immunobiology of Acquired Equine Polyneuropathy (AEP); a key to the aetiology?
This is a cooperation between Norges miljø- og biovitenskaplige universitet (NMBU) Oslo, Norge and SVA with First amanuensis Karin Hultin Jäderlund as main applicant.
Acquired Equine Polyneuropathy (AEP) is a serious farm-related disease of the equine peripheral nervous system, of unclear aetiology. An environmental, probably forage-related association has been suggested from data gathered hitherto. Nerve biopsy specimens from affected horses have displayed unique accumulations in the Schwann cell perikaryon and a demyelinating polyneuropathy with inflammatory infiltrates in myelinated nerve fibres.
Determining what comes first; the intracellullar alterations or the endoneural inflammation, has not been possible from routine histopathology. We therefore intend to investigate the pathobiology and immune cascade at the level of tissue-, cell-, organelle- and molecular biology in different stages of AEP. The aim is to elucidate important steps of the disease pathogenesis, thereby approaching the aetiology and identifying targets for prophylaxis and specific therapies.