Sino-Swedish Integrated Multisectorial Partnership for Containment of Antibiotic resistance (IMPACT)
To minimize emergence and dissemination of antibiotic resistance (ABR) a holistic one-health approach is called for at national and international levels. This project aims to (i) increase basic knowledge of the complex routes of dissemination of ABR between sectors (humans, animals, the environment), with specific focus on MRSA and ESBL-producing E. coli and Klebsiella pneumoniae (ii) increase basic knowledge of factors contributing to irrational use of antibiotics (ABs) in humans and animals, (iii) integrate this new knowledge with existing evidence to design and pilot interventions aiming to limit development and spread of ABR, and (iv) promote adequate infection prevention and control and access to effective ABs for humans and animals for improved public and animal health and consequently efficient, sustainable animal food production. Molecular investigations will map and correlate the occurrence of ABR clones in; humans (commensal, clinical isolates), animals (household, farm animals), food, drinking water and the environment (water, sewage, manure). Antibiotic residues will be mapped as well as AB use (humans and animals), perceptions, knowledge, attitudes and practice among key stakeholders (community members, farmers, health care providers, animal health advisors). The project is a collaboration between Swedish and Chinese partners; Public Health Agency of Sweden, The Swedish National Veterinary institute, Karolinska Insitute, Linköping University, The Swedish National Food Agency, Zhejiang University, China Agricultural University and Shandong University. The project will be conducted in Shandong Province, China.