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2011 - 2014

Attributing human cases of campylobacteriosis to their sources as a tool for targeted interventions

Campylobacteriosis is the most commonly reported zoonosis in Sweden and in EU and a reduction in incidence would be of substantial societal value. Today we lack knowledge on the relative impact of different sources of this infection and because transmission is often indirect, from several animal species and through many different routes, this is a highly complex issue to address. It is, however, imperative in order to identifiy and prioritise control measures. This project will develop tools for source attribution of human campylobacteriosis, which has not previously been done under Swedish conditions. A major strength compared to previous foreign work is that the analysis will build upon prospective collection of Campylobacter isolates. This is to ensure that Campylobacter isolates found in reservoirs accurately reflects human exposure during the same time period. All surveys will be designed to provide a representative sample of isolates. They will cover human cases as well as the sources poultry, cattle, pigs, sheep, dogs, raw water and recreational waters. Imported food will also be included. Subtyping will be performed using Multilocus Sequence Typing (MLST). The source attribution model is based on Bayesian methodology and allows estimation of the proportion of human cases emanating from different underlying sources, by comparing the distribution of subtypes in human cases and in the sources. In this way, the impact of each source can be quantified.

Senast uppdaterad : 2015-06-25