Smittsam livmodersinflammation i Europa

The goal of this project is to improve the control and understanding of contagious equine metritis (CEM), a notifiable sexually transmitted disease in horses caused by Taylorella equigenitalis. CEM can cause infertility, shortened estrous cycles, and vaginal discharge in mares, while stallions and geldings often act as asymptomatic carriers. The disease spreads via sexual contact, contaminated semen, fomites, poor hygiene, and close contact. CEM poses a significant economic burden on the equine industry due to reduced fertility, and additional costs and restrictions posed by the regulatory bodies. Due to the bacterium’s fastidious growth, PCR is the preferred method for rapid detection, but this limits isolate recovery for further characterization. An increase in reported CEM cases across Europe since 2017 and the re-emergence in countries such as Sweden and Denmark highlights the need for improved surveillance and control, especially as outbreaks may involve cross-border transmission.

This project aims to improve laboratory methods and promote harmonization across the collaborating institutes with focus on characterization of the genomic diversity of T. equigenitalis in Europe, knowledge exchange, and sharing of protocols between countries. We will link genetic data to epidemiological factors like breed and animal movement to understand transmission dynamics. Screening isolates from different countries may further help detect resistance patterns, which could advise on treatment protocols.

Outcomes include a clearer understanding of T. equigenitalis transmission, improved harmonization of culture and AST protocols through exchange among partner laboratories, and enhanced collaboration. This work will lay the foundation for improved disease control and future research efforts.